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26,000-PERSON STUDY: FISH OIL AND VITAMIN D PILLS NO GUARD AGAINST CANCER OR SERIOUS HEART TROUBLE

By Liz Szabo
Kaiser Health News

A widely anticipated study has concluded that neither vitamin D nor fish oil supplements prevent cancer or serious heart-related problems in healthy older people, according to research presented Nov. 10 at the American Heart Association Scientific Sessions. Researchers defined serious heart problems as the combined rate of heart attacks, stroke and heart-related deaths.

Although hundreds of studies of these supplements have been published over the years, the new clinical trial — a federally funded project involving nearly 26,000 people — is the strongest and most definitive examination yet, said Clifford Rosen, MD and a senior scientist at the Maine Medical Center Research Institute who was not involved in the research.

Doctors have been keenly interested in learning the supplements’ true value, given their tremendous popularity with patients. A 2017 study found that 26 percent of Americans age 60 and older take vitamin D supplements, while 22 percent take pills containing omega-3 fatty acids, a key ingredient in fish oil.

The new study also suggests there’s no reason for people to undergo routine blood tests for vitamin D, said Dr. Rosen, who co-wrote an accompanying editorial. (Both were published in the New England Journal of Medicine.). That’s because the study found that patients’ vitamin D levels made no difference in their risk of cancer or serious heart issues, he said.

Even people who began the study with clear vitamin D deficiency got no benefit from taking the supplements, which provided 2,000 international units a day. This amount is equal to one or two of the vitamin D pills typically sold in stores.

A recent Kaiser Health News story reported that vitamin D testing has become a huge business for commercial labs — and an enormous expense for taxpayers. Doctors ordered more than 10 million vitamin D tests for Medicare patients in 2016 — an increase of 547 percent since 2007 — at a cost of $365 million.

“It’s time to stop it,” Dr. Rosen said of vitamin D testing. “There’s no justification.”
JoAnn Manson, MD and the study’s lead author, agrees that her results don’t support screening healthy people for vitamin D deficiency.

But she doesn’t see her study as entirely negative.

Dr. Manson notes that her team found no serious side effects from taking either fish oil or vitamin D supplements. “If you’re already taking fish oil or vitamin D, our results would not provide a clear reason to stop,” she said.

Dr. Manson notes that a deeper look into the data suggested possible benefits.
When researchers singled out heart attacks — rather than the rate of all serious heart problems combined — they saw that fish oil appeared to reduce heart attacks by 28 percent, Dr. Manson said. As for vitamin D, it appeared to reduce cancer deaths — although not cancer diagnoses — by 25 percent.

But slicing the data into smaller segments — with fewer patients in each group — can produce unreliable results, said Dr. Barnett Kramer, director of the cancer prevention division at the National Cancer Institute. The links between fish oil and heart attacks — and vitamin D and cancer death — could be due to chance, Dr. Kramer said.

Experts agree that vitamin D is important for bone health. Researchers didn’t report on its effect on bones in these papers, however. Instead, they looked at areas where vitamin D’s benefits haven’t been definitely proven, such as cancer and heart disease. Although preliminary studies have suggested vitamin D can prevent heart disease and cancer, more rigorous studies have disputed those findings.

Dr. Manson and her colleagues plan to publish data on the supplements’ effects on other areas of health in coming months, including diabetes, memory and mental functioning, autoimmune disease, respiratory infections and depression.

Consumers who want to reduce their risk of cancer and heart disease can follow other proven strategies, according to Alex Krist, MD and a professor of family medicine and population health at Virginia Commonwealth University.

“People should continue to focus on known factors to reduce cancer and heart disease: Eat right, exercise, don’t smoke, control high blood pressure, take a statin if you are high risk,” saidDr. Krist said. VTN.

 

Liz Szabo, the Kaiser Health News John A. Hartford Senior Correspondent, is an enterprise reporter focusing on acute care and end-of-life issues. She has an extensive background in medical reporting, including 12 years as a health writer at USA TODAY, where she led a yearlong series on the neglect of people with mental illness. Her work for USA TODAY won the Victor Cohn Prize for Excellence in Medical Science Reporting. Her investigation of dangerous doctors, written while working at The Virginian-Pilot in Norfolk, Va. in 2002, won two National Press Club awards and led Virginia lawmakers to toughen state laws for disciplining physicians. She can be contacted by email at Slszabo@kff.org .

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Larry Storer

Larry Storer

Larry Storer has been editor of Vein Therapy News for 10 years. He has edited computer, shelter and medical publications at Publications & Communications LP for 30 years. He was also a corporate vice president and editorial director before retiring. Larry graduated from Baylor University with a BA in journalism and an MA in communications; and from Lamar University with a MED in school administration. He taught beginning and advanced reporting, beginning and advanced editing and editorial writing at Baylor University. Larry was a reporter, and city and news editor of the Beaumont Journal, and opinion editor at the Beaumont Enterprise and Beaumont Enterprise-Journal. He was also the founding managing editor of the Yuba City (California) Daily Independent-Herald.